Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver

The liver is an immune-privileged organ that can deactivate autoreactive T cells. Yet in autoimmune hepatitis (AIH), autoreactive T cells can defy hepatic control and attack the liver. To elucidate how tolerance to self-antigens is lost during AIH pathogenesis, we generated a spontaneous mouse model...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Preti, Max, Schlott, Lena, Lübbering, David, Krzikalla, Daria, Müller, Anna-Lena, Schuran, Fenja A., Poch, Tobias, Schakat, Miriam, Weidemann, Sören, Lohse, Ansgar W., Weiler-Normann, Christina, Sebode, Marcial, Schwinge, Dorothee, Schramm, Christoph, Carambia, Antonella, Herkel, Johannes
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026180/
https://ncbi.nlm.nih.gov/pubmed/33600378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.141462
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