CD4+ T-Cell Help Is Required for Effective CD8+ T Cell-Mediated Resolution of Acute Viral Hepatitis in Mice

Cytotoxic CD8+ T cells are essential for the control of viral liver infections, such as those caused by HBV or HCV. It is not entirely clear whether CD4+ T-cell help is necessary for establishing anti-viral CD8+ T cell responses that successfully control liver infection. To address the role of CD4+...

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Bibliographic Details
Main Authors: Trautmann, Tanja, Kozik, Jan-Hendrik, Carambia, Antonella, Richter, Kirsten, Lischke, Timo, Schwinge, Dorothee, Mittrücker, Hans-Willi, Lohse, Ansgar W., Oxenius, Annette, Wiegard, Christiane, Herkel, Johannes
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3897723/
https://ncbi.nlm.nih.gov/pubmed/24466045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0086348
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