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HMGB1 neutralization is associated with bacterial translocation during acetaminophen hepatotoxicity
BACKGROUND: Acetaminophen (APAP) hepatotoxicity is associated with a high rate of gram-negative enteric bacterial infection; however, the underlying mechanism is still unknown. APAP overdose induces massive hepatocyte necrosis, necrotic tissue releases high mobility group B1 (HMGB1) and exogenous HM...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3985724/ https://ncbi.nlm.nih.gov/pubmed/24708589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-230X-14-66 |
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