Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

We have previously shown that a loss of stromal Cav-1 is a biomarker of poor prognosis in breast cancers. Mechanistically, a loss of Cav-1 induces the metabolic reprogramming of stromal cells, with increased autophagy/mitophagy, mitochondrial dysfunction and aerobic glycolysis. As a consequence, Cav...

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Main Authors: Guido, Carmela, Whitaker-Menezes, Diana, Capparelli, Claudia, Balliet, Renee, Lin, Zhao, Pestell, Richard G., Howell, Anthony, Aquila, Saveria, Andò, Sebastiano, Martinez-Outschoorn, Ubaldo, Sotgia, Federica, Lisanti, Michael P.
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2012
Teme:
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442913/
https://ncbi.nlm.nih.gov/pubmed/22874531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21384
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