Mitochondrial Fission Induces Glycolytic Reprogramming in Cancer-Associated Myofibroblasts, Driving Stromal Lactate Production, and Early Tumor Growth

Recent studies have suggested that cancer cells behave as metabolic parasites, by inducing oxidative stress in adjacent normal fibroblasts. More specifically, oncogenic mutations in cancer cells lead to ROS production and the “secretion” of hydrogen peroxide species. Oxidative stress in stromal fibr...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Guido, Carmela, Whitaker-Menezes, Diana, Lin, Zhao, Pestell, Richard G., Howell, Anthony, Zimmers, Teresa A., Casimiro, Mathew C., Aquila, Saveria, Ando’, Sebastiano, Martinez-Outschoorn, Ubaldo E., Sotgia, Federica, Lisanti, Michael P.
Format: Artigo
Langue:Inglês
Publié: Impact Journals LLC 2012
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3478457/
https://ncbi.nlm.nih.gov/pubmed/22878233
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