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Phosphorylation is the switch that turns PEA-15 from tumor suppressor to tumor promoter

Abnormal ERK signaling is implicated in many human diseases including cancer. This signaling cascade is a good target for the therapy of certain malignancies because of its important role in regulating cell proliferation and survival. The small phosphoprotein PEA-15 is a potent regulator of the ERK...

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Bibliografiske detaljer
Main Authors: Sulzmaier, Florian J., Opoku-Ansah, John, Ramos, Joe W.
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3442804/
https://ncbi.nlm.nih.gov/pubmed/22694972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/sgtp.20021
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