Role of Gab1 in UV-Induced c-Jun NH(2)-Terminal Kinase Activation and Cell Apoptosis

Exposure of mammalian cells to UV irradiation leads to activation of the c-Jun NH(2)-terminal protein kinase (JNK) pathway, which is associated with cell apoptosis. However, the molecular mechanism for JNK activation by UV exposure is not fully understood. We show here an essential role of a multisu...

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Detalhes bibliográficos
Main Authors: Sun, Yingqing, Yuan, Jing, Liu, Houqi, Shi, Zhongqing, Baker, Kelly, Vuori, Kristiina, Wu, Jie, Feng, Gen-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC344197/
https://ncbi.nlm.nih.gov/pubmed/14749370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.4.1531-1539.2004
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