Profiling Environmental Chemicals for Activity in the Antioxidant Response Element Signaling Pathway Using a High Throughput Screening Approach

Background: Oxidative stress has been implicated in the pathogenesis of a variety of diseases ranging from cancer to neurodegeneration, highlighting the need to identify chemicals that can induce this effect. The antioxidant response element (ARE) signaling pathway plays an important role in the ame...

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Main Authors: Shukla, Sunita J, Huang, Ruili, Simmons, Steven O, Tice, Raymond R, Witt, Kristine L, VanLeer, Danielle, Ramabhadran, Ram, Austin, Christopher P, Xia, Menghang
Formato: Artigo
Idioma:Inglês
Publicado: National Institute of Environmental Health Sciences 2012
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3440086/
https://ncbi.nlm.nih.gov/pubmed/22551509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1104709
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