High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death

Human ATAD5 is a biomarker for identifying genotoxic compounds because ATAD5 protein levels increase posttranscriptionally in response to DNA damage. We screened over 4,000 compounds with a cell-based quantitative high-throughput ATAD5-luciferase assay detecting genotoxic compounds. We identified 22...

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Detalhes bibliográficos
Main Authors: Fox, Jennifer T., Sakamuru, Srilatha, Huang, Ruili, Teneva, Nedelina, Simmons, Steven O., Xia, Menghang, Tice, Raymond R., Austin, Christopher P., Myung, Kyungjae
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325711/
https://ncbi.nlm.nih.gov/pubmed/22431602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114278109
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