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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death
Human ATAD5 is a biomarker for identifying genotoxic compounds because ATAD5 protein levels increase posttranscriptionally in response to DNA damage. We screened over 4,000 compounds with a cell-based quantitative high-throughput ATAD5-luciferase assay detecting genotoxic compounds. We identified 22...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3325711/ https://ncbi.nlm.nih.gov/pubmed/22431602 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114278109 |
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