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Assessment of the DNA Damaging Potential of Environmental Chemicals Using a Quantitative High-Throughput Screening Approach to Measure p53 Activation
Genotoxicity potential is a critical component of any comprehensive toxicological profile. Compounds that induce DNA or chromosomal damage often activate p53, a transcription factor essential to cell cycle regulation. Thus, within the U.S. Tox21 Program, we screened a library of ~10,000 (~8,300 uniq...
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| Publicado en: | Environ Mol Mutagen |
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| Autores principales: | , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5555817/ https://ncbi.nlm.nih.gov/pubmed/28714573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22112 |
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