Assessment of the DNA Damaging Potential of Environmental Chemicals Using a Quantitative High-Throughput Screening Approach to Measure p53 Activation

Genotoxicity potential is a critical component of any comprehensive toxicological profile. Compounds that induce DNA or chromosomal damage often activate p53, a transcription factor essential to cell cycle regulation. Thus, within the U.S. Tox21 Program, we screened a library of ~10,000 (~8,300 uniq...

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Veröffentlicht in:Environ Mol Mutagen
Hauptverfasser: Witt, Kristine L., Hsieh, Jui-Hua, Smith-Roe, Stephanie L., Xia, Menghang, Huang, Ruili, Auerbach, Scott S., Hur, Junguk, Tice, Raymond R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555817/
https://ncbi.nlm.nih.gov/pubmed/28714573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22112
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