Assessment of the DNA Damaging Potential of Environmental Chemicals Using a Quantitative High-Throughput Screening Approach to Measure p53 Activation

Genotoxicity potential is a critical component of any comprehensive toxicological profile. Compounds that induce DNA or chromosomal damage often activate p53, a transcription factor essential to cell cycle regulation. Thus, within the U.S. Tox21 Program, we screened a library of ~10,000 (~8,300 uniq...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Environ Mol Mutagen
Main Authors: Witt, Kristine L., Hsieh, Jui-Hua, Smith-Roe, Stephanie L., Xia, Menghang, Huang, Ruili, Auerbach, Scott S., Hur, Junguk, Tice, Raymond R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5555817/
https://ncbi.nlm.nih.gov/pubmed/28714573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/em.22112
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados