An ectopic CTCF-dependent transcriptional insulator influences the choice of Vβ gene segments for VDJ recombination at TCRβ locus

Insulators regulate transcription as they modulate the interactions between enhancers and promoters by organizing the chromatin into distinct domains. To gain better understanding of the nature of chromatin domains defined by insulators, we analyzed the ability of an insulator to interfere in VDJ re...

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Bibliographische Detailangaben
Hauptverfasser: Shrimali, Sweety, Srivastava, Surabhi, Varma, Garima, Grinberg, Alex, Pfeifer, Karl, Srivastava, Madhulika
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
Schlagworte:
Gene Regulation, Chromatin and Epigenetics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439925/
https://ncbi.nlm.nih.gov/pubmed/22718969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gks556
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