Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

BACKGROUND: β-site APP cleaving enzyme 1 (BACE1) cleaves β-amyloid precursor protein (APP) to initiate the production of β-amyloid (Aβ), the prime culprit in Alzheimer’s disease (AD). Dysregulation of the intracellular trafficking of BACE1 may affect Aβ generation, contributing to AD pathology. In t...

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Bibliografske podrobnosti
Main Authors: Zhao, Yonghao, Wang, Yunshu, Yang, Jiaye, Wang, Xin, Zhao, Yingjun, Zhang, Xian, Zhang, Yun-wu
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3439308/
https://ncbi.nlm.nih.gov/pubmed/22709416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-7-30
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