(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

(G2019S) mutation of leucine-rich repeat kinase 2 (LRRK2) is the most common genetic cause of both familial and sporadic Parkinson's disease (PD) cases. Twelve- to sixteen-month-old (G2019S) LRRK2 transgenic mice prepared by us displayed progressive degeneration of substantia nigra pars compact...

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Bibliographische Detailangaben
Hauptverfasser: Chen, C-Y, Weng, Y-H, Chien, K-Y, Lin, K-J, Yeh, T-H, Cheng, Y-P, Lu, C-S, Wang, H-L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2012
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438494/
https://ncbi.nlm.nih.gov/pubmed/22539006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2012.42
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