Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemical features that are largely indistinguishab...

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Detalhes bibliográficos
Main Authors: Ramonet, David, Daher, João Paulo L., Lin, Brian M., Stafa, Klodjan, Kim, Jaekwang, Banerjee, Rebecca, Westerlund, Marie, Pletnikova, Olga, Glauser, Liliane, Yang, Lichuan, Liu, Ying, Swing, Deborah A., Beal, M. Flint, Troncoso, Juan C., McCaffery, J. Michael, Jenkins, Nancy A., Copeland, Neal G., Galter, Dagmar, Thomas, Bobby, Lee, Michael K., Dawson, Ted M., Dawson, Valina L., Moore, Darren J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071839/
https://ncbi.nlm.nih.gov/pubmed/21494637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0018568
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