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PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

Mutations in the ATP13A2 gene (PARK9, OMIM 610513) cause autosomal recessive, juvenile-onset Kufor-Rakeb syndrome and early-onset parkinsonism. ATP13A2 is an uncharacterized protein belonging to the P(5)-type ATPase subfamily that is predicted to regulate the membrane transport of cations. The physi...

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Bibliografski detalji
Glavni autori: Ramonet, David, Podhajska, Agata, Stafa, Klodjan, Sonnay, Sarah, Trancikova, Alzbeta, Tsika, Elpida, Pletnikova, Olga, Troncoso, Juan C., Glauser, Liliane, Moore, Darren J.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465694/
https://ncbi.nlm.nih.gov/pubmed/22186024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr606
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