Thiol peroxidases ameliorate LRRK2 mutant-induced mitochondrial and dopaminergic neuronal degeneration in Drosophila

Mutations in leucine-rich repeat kinase 2 (LRRK2) are common causes of familial Parkinson's disease (PD). LRRK2 has been shown to bind peroxiredoxin-3 (PRDX3), the most important scavenger of hydrogen peroxide in the mitochondria, in vitro. Here, we examined the interactions of LRRK2 and PRDX3...

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Main Authors: Angeles, Dario C., Ho, Patrick, Chua, Ling Ling, Wang, Cheng, Yap, Yan Wann, Ng, Cheehoe, Zhou, Zhi dong, Lim, Kah-Leong, Wszolek, Zbigniew K., Wang, Hong Y., Tan, Eng King
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4030771/
https://ncbi.nlm.nih.gov/pubmed/24459295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu026
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