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Antioxidants inhibit neuronal toxicity in Parkinson's disease‐linked LRRK2
Mutations in leucine‐rich repeat kinase‐2 are the most common cause of familial Parkinson's disease. The prevalent G2019S mutation increase oxidative, kinase and toxic activity and inhibit endogenous peroxidases. We initially screened a library of 84 antioxidants and identified seven phenolic c...
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| Publicado no: | Ann Clin Transl Neurol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4818746/ https://ncbi.nlm.nih.gov/pubmed/27081659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.282 |
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