Antioxidants inhibit neuronal toxicity in Parkinson's disease‐linked LRRK2

Mutations in leucine‐rich repeat kinase‐2 are the most common cause of familial Parkinson's disease. The prevalent G2019S mutation increase oxidative, kinase and toxic activity and inhibit endogenous peroxidases. We initially screened a library of 84 antioxidants and identified seven phenolic c...

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Detaylı Bibliyografya
Yayımlandı:Ann Clin Transl Neurol
Asıl Yazarlar: Angeles, Dario C., Ho, Patrick, Dymock, Brian W., Lim, Kah‐Leong, Zhou, Zhi‐Dong, Tan, Eng‐King
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2016
Konular:
Brief Communication
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818746/
https://ncbi.nlm.nih.gov/pubmed/27081659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.282
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