Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition

Fast, accurate nucleotide incorporation by polymerases facilitates expression and maintenance of genomes. Many polymerases use conformational dynamics of a conserved α-helix to permit efficient nucleotide addition only when the correct nucleotide substrate is bound. This α-helix is missing in struct...

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Autores principales: Yang, Xiaorong, Smidansky, Eric D., Maksimchuk, Kenneth R., Lum, David, Welch, Jesse L., Arnold, Jamie J., Cameron, Craig E., Boehr, David D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438331/
https://ncbi.nlm.nih.gov/pubmed/22819218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.06.012
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