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Motif D of viral RNA-dependent RNA polymerases determines efficiency and fidelity of nucleotide addition
Fast, accurate nucleotide incorporation by polymerases facilitates expression and maintenance of genomes. Many polymerases use conformational dynamics of a conserved α-helix to permit efficient nucleotide addition only when the correct nucleotide substrate is bound. This α-helix is missing in struct...
Tallennettuna:
| Päätekijät: | , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3438331/ https://ncbi.nlm.nih.gov/pubmed/22819218 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.06.012 |
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