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Energy landscape analysis of native folding of the prion protein yields the diffusion constant, transition path time, and rates
Protein folding is described conceptually in terms of diffusion over a configurational free-energy landscape, typically reduced to a one-dimensional profile along a reaction coordinate. In principle, kinetic properties can be predicted directly from the landscape profile using Kramers theory for dif...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3437844/ https://ncbi.nlm.nih.gov/pubmed/22908253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206190109 |
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