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Energy landscape analysis of native folding of the prion protein yields the diffusion constant, transition path time, and rates

Protein folding is described conceptually in terms of diffusion over a configurational free-energy landscape, typically reduced to a one-dimensional profile along a reaction coordinate. In principle, kinetic properties can be predicted directly from the landscape profile using Kramers theory for dif...

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Main Authors: Yu, Hao, Gupta, Amar Nath, Liu, Xia, Neupane, Krishna, Brigley, Angela M., Sosova, Iveta, Woodside, Michael T.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437844/
https://ncbi.nlm.nih.gov/pubmed/22908253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206190109
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