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Protein misfolding occurs by slow diffusion across multiple barriers in a rough energy landscape
The timescale for the microscopic dynamics of proteins during conformational transitions is set by the intrachain diffusion coefficient, D. Despite the central role of protein misfolding and aggregation in many diseases, it has proven challenging to measure D for these processes because of their het...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4500230/ https://ncbi.nlm.nih.gov/pubmed/26109573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419197112 |
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