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Comparing the energy landscapes for native folding and aggregation of PrP

Protein sequences are evolved to encode generally one folded structure, out of a nearly infinite array of possible folds. Underlying this code is a funneled free energy landscape that guides folding to the native conformation. Protein misfolding and aggregation are also a manifestation of free-energ...

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Bibliografski detalji
Izdano u:Prion
Glavni autori: Dee, Derek R., Woodside, Michael T.
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4981195/
https://ncbi.nlm.nih.gov/pubmed/27191683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336896.2016.1173297
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