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Protein misfolding occurs by slow diffusion across multiple barriers in a rough energy landscape
The timescale for the microscopic dynamics of proteins during conformational transitions is set by the intrachain diffusion coefficient, D. Despite the central role of protein misfolding and aggregation in many diseases, it has proven challenging to measure D for these processes because of their het...
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| Veröffentlicht in: | Proc Natl Acad Sci U S A |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4500230/ https://ncbi.nlm.nih.gov/pubmed/26109573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1419197112 |
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