Specific deletion of Na(V)1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome

Heterozygous loss-of-function mutations in the brain sodium channel Na(V)1.1 cause Dravet syndrome (DS), a pharmacoresistant infantile-onset epilepsy syndrome with comorbidities of cognitive impairment and premature death. Previous studies using a mouse model of DS revealed reduced sodium currents a...

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Detaylı Bibliyografya
Asıl Yazarlar: Cheah, Christine S., Yu, Frank H., Westenbroek, Ruth E., Kalume, Franck K., Oakley, John C., Potter, Gregory B., Rubenstein, John L., Catterall, William A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2012
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437823/
https://ncbi.nlm.nih.gov/pubmed/22908258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1211591109
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