Immunotherapeutic Synergy Between Anti-CD137 mAb and Intratumoral Administration of a Cytopathic Semliki Forest Virus Encoding IL-12

Intratumoral injection of Semliki Forest virus encoding interleukin-12 (SFV-IL-12) combines acute expression of IL-12 and stressful apoptosis of infected malignant cells. Agonist antibodies directed to costimulatory receptor CD137 (4-1BB) strongly amplify pre-existing cellular immune responses towar...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Quetglas, José I, Dubrot, Juan, Bezunartea, Jaione, Sanmamed, Miguel F, Hervas-Stubbs, Sandra, Smerdou, Cristian, Melero, Ignacio
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2012
Assuntos:
Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437571/
https://ncbi.nlm.nih.gov/pubmed/22735380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.56
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares