Essential complicity of perforin-granzyme and FAS-L mechanisms to achieve tumor rejection following treatment with anti-CD137 mAb

BACKGROUND: Treatment with agonist anti-CD137 (4-1BB) immunostimulatory monoclonal antibodies elicits complete tumor regressions in a number of transplanted hematological and solid malignancies in mice. Rejection is mainly dependent on cytotoxic T lymphocytes (CTL) and IFNγ, although a role for NK c...

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Detalhes bibliográficos
Main Authors: Morales-Kastresana, Aizea, Catalán, Elena, Hervás-Stubbs, Sandra, Palazón, Asis, Azpilikueta, Arantza, Bolaños, Elixabet, Anel, Alberto, Pardo, Julián, Melero, Ignacio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Short Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3987045/
https://ncbi.nlm.nih.gov/pubmed/24764534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2051-1426-1-3
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