Immunotherapeutic Synergy Between Anti-CD137 mAb and Intratumoral Administration of a Cytopathic Semliki Forest Virus Encoding IL-12

Intratumoral injection of Semliki Forest virus encoding interleukin-12 (SFV-IL-12) combines acute expression of IL-12 and stressful apoptosis of infected malignant cells. Agonist antibodies directed to costimulatory receptor CD137 (4-1BB) strongly amplify pre-existing cellular immune responses towar...

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Detalhes bibliográficos
Main Authors: Quetglas, José I, Dubrot, Juan, Bezunartea, Jaione, Sanmamed, Miguel F, Hervas-Stubbs, Sandra, Smerdou, Cristian, Melero, Ignacio
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437571/
https://ncbi.nlm.nih.gov/pubmed/22735380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.56
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