Thioredoxin Reductase Inhibition Elicits Nrf2-Mediated Responses in Clara Cells: Implications for Oxidant-Induced Lung Injury

Aims: Pulmonary oxygen toxicity contributes to lung injury in newborn and adult humans. We previously reported that thioredoxin reductase (TrxR1) inhibition with aurothioglucose (ATG) attenuates hyperoxic lung injury in adult mice. The present studies tested the hypothesis that TrxR1 inhibition prot...

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Hlavní autoři: Locy, Morgan L., Rogers, Lynette K., Prigge, Justin R., Schmidt, Edward E., Arnér, Elias S.J., Tipple, Trent E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2012
Témata:
Original Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437047/
https://ncbi.nlm.nih.gov/pubmed/22607006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4377
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