Thioredoxin Reductase Inhibition Attenuates Neonatal Hyperoxic Lung Injury and Enhances Nuclear Factor E2–Related Factor 2 Activation

Oxygen toxicity and antioxidant deficiencies contribute to the development of bronchopulmonary dysplasia. Aurothioglucose (ATG) and auranofin potently inhibit thioredoxin reductase-1 (TrxR1), and TrxR1 disruption activates nuclear factor E2–related factor 2 (Nrf2), a regulator of endogenous antioxid...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Am J Respir Cell Mol Biol
Autors principals: Li, Qian, Wall, Stephanie B., Ren, Changchun, Velten, Markus, Hill, Cynthia L., Locy, Morgan L., Rogers, Lynette K., Tipple, Trent E.
Format: Artigo
Idioma:Inglês
Publicat: American Thoracic Society 2016
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5023024/
https://ncbi.nlm.nih.gov/pubmed/27089175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0228OC
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars