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Thioredoxin Reductase Inhibition Elicits Nrf2-Mediated Responses in Clara Cells: Implications for Oxidant-Induced Lung Injury

Aims: Pulmonary oxygen toxicity contributes to lung injury in newborn and adult humans. We previously reported that thioredoxin reductase (TrxR1) inhibition with aurothioglucose (ATG) attenuates hyperoxic lung injury in adult mice. The present studies tested the hypothesis that TrxR1 inhibition prot...

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Bibliografische gegevens
Hoofdauteurs: Locy, Morgan L., Rogers, Lynette K., Prigge, Justin R., Schmidt, Edward E., Arnér, Elias S.J., Tipple, Trent E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Mary Ann Liebert, Inc. 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437047/
https://ncbi.nlm.nih.gov/pubmed/22607006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.4377
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