The thioredoxin reductase inhibitor auranofin induces heme oxygenase-1 in lung epithelial cells via Nrf2-dependent mechanisms

Thioredoxin reductase-1 (TXNRD1) inhibition effectively activates nuclear factor (erythroid-derived 2)-like 2 (Nrf2) responses and attenuates lung injury in acute respiratory distress syndrome (ARDS) and bronchopulmonary dysplasia (BPD) models. Upon TXNRD1 inhibition, heme oxygenase-1 (HO-1) is disp...

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Bibliographic Details
Published in:Am J Physiol Lung Cell Mol Physiol
Main Authors: Dunigan, Katelyn, Li, Qian, Li, Rui, Locy, Morgan L., Wall, Stephanie, Tipple, Trent E.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2018
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6230877/
https://ncbi.nlm.nih.gov/pubmed/30024305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00214.2018
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