Structural Factors That Determine Selectivity of a High Fidelity DNA Polymerase for Deoxy-, Dideoxy-, and Ribonucleotides

In addition to discriminating against base pair mismatches, DNA polymerases exhibit a high degree of selectivity for deoxyribonucleotides over ribo- or dideoxynucleotides. It has been proposed that a single active site residue (steric gate) blocks productive binding of nucleotides containing 2′-hydr...

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Bibliographic Details
Main Authors: Wang, Weina, Wu, Eugene Y., Hellinga, Homme W., Beese, Lorena S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436578/
https://ncbi.nlm.nih.gov/pubmed/22648417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.366609
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