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Ribonucleotide Discrimination and Reverse Transcription by the Human Mitochondrial DNA Polymerase

During DNA synthesis, DNA polymerases must select against ribonucleotides, present at much higher levels compared with deoxyribonucleotides. Most DNA polymerases are equipped to exclude ribonucleotides from their active site through a bulky side chain residue that can sterically block the 2′-hydroxy...

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Bibliographic Details
Main Authors: Kasiviswanathan, Rajesh, Copeland, William C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173122/
https://ncbi.nlm.nih.gov/pubmed/21778232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.252460
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