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Ribonucleotide Discrimination and Reverse Transcription by the Human Mitochondrial DNA Polymerase

During DNA synthesis, DNA polymerases must select against ribonucleotides, present at much higher levels compared with deoxyribonucleotides. Most DNA polymerases are equipped to exclude ribonucleotides from their active site through a bulky side chain residue that can sterically block the 2′-hydroxy...

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Hlavní autoři: Kasiviswanathan, Rajesh, Copeland, William C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3173122/
https://ncbi.nlm.nih.gov/pubmed/21778232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.252460
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