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Structural evidence for the rare tautomer hypothesis of spontaneous mutagenesis
Even though high-fidelity polymerases copy DNA with remarkable accuracy, some base-pair mismatches are incorporated at low frequency, leading to spontaneous mutagenesis. Using high-resolution X-ray crystallographic analysis of a DNA polymerase that catalyzes replication in crystals, we observe that...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3203791/ https://ncbi.nlm.nih.gov/pubmed/22006298 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1114496108 |
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