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Biochemical Characterization of Human Tyrosyl-DNA Phosphodiesterase 2 (TDP2/TTRAP): A Mg(2+)/Mn(2+)-DEPENDENT PHOSPHODIESTERASE SPECIFIC FOR THE REPAIR OF TOPOISOMERASE CLEAVAGE COMPLEXES

TDP2 is a multifunctional enzyme previously known for its role in signal transduction as TRAF and TNF receptor-associated protein (TTRAP) and ETS1-associated protein 2 (EAPII). The gene has recently been renamed TDP2 because it plays a critical role for the repair of topoisomerase II cleavage comple...

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Detalhes bibliográficos
Main Authors: Gao, Rui, Huang, Shar-yin N., Marchand, Christophe, Pommier, Yves
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436327/
https://ncbi.nlm.nih.gov/pubmed/22822062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.393983
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