The E3 Ubiquitin Ligase Protein Associated with Myc (Pam) Regulates Mammalian/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling in Vivo through N- and C-terminal Domains

Pam and its homologs (the PHR protein family) are large E3 ubiquitin ligases that function to regulate synapse formation and growth in mammals, zebrafish, Drosophila, and Caenorhabditis elegans. Phr1-deficient mouse models (Phr1(Δ8,9) and Phr1(Magellan), with deletions in the N-terminal putative gua...

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Bibliographic Details
Main Authors: Han, Sangyeul, Kim, Sun, Bahl, Samira, Li, Lin, Burande, Clara F., Smith, Nicole, James, Marianne, Beauchamp, Roberta L., Bhide, Pradeep, DiAntonio, Aaron, Ramesh, Vijaya
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436263/
https://ncbi.nlm.nih.gov/pubmed/22798074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.353987
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