The E3 Ubiquitin Ligase Protein Associated with Myc (Pam) Regulates Mammalian/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling in Vivo through N- and C-terminal Domains

Pam and its homologs (the PHR protein family) are large E3 ubiquitin ligases that function to regulate synapse formation and growth in mammals, zebrafish, Drosophila, and Caenorhabditis elegans. Phr1-deficient mouse models (Phr1(Δ8,9) and Phr1(Magellan), with deletions in the N-terminal putative gua...

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Detalhes bibliográficos
Main Authors: Han, Sangyeul, Kim, Sun, Bahl, Samira, Li, Lin, Burande, Clara F., Smith, Nicole, James, Marianne, Beauchamp, Roberta L., Bhide, Pradeep, DiAntonio, Aaron, Ramesh, Vijaya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436263/
https://ncbi.nlm.nih.gov/pubmed/22798074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.353987
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