NKG2D signaling on CD8(+) T cells represses T-bet and rescues CD4-unhelped CD8(+) T cell memory recall but not effector responses

CD4-unhelped CD8(+) T cells are functionally-defective cells primed in the absence of CD4(+) T cell help and present a critical problem. Based on the co-stimulatory and non-canonical roles of NKG2D on CD8(+) T cells, we investigated its ability to rescue these immunologically-impotent cells. We demo...

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Autores principales: Zloza, Andrew, Kohlhapp, Frederick J., Lyons, Gretchen E., Schenkel, Jason M., Moore, Tamson V., Lacek, Andrew T., O’Sullivan, Jeremy A., Varanasi, Vineeth, Williams, Jesse W., Jagoda, Michael C., Bellavance, Emily C., Marzo, Amanda L., Thomas, Paul G., Zafirova, Biljana, Polić, Bojan, Al-Harthi, Lena, Sperling, Anne I., Guevara-Patiño, José A.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436127/
https://ncbi.nlm.nih.gov/pubmed/22366950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2683
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