Priming with very low-affinity peptide ligands gives rise to CD8(+) T-cell effectors with enhanced function but with greater susceptibility to transforming growth factor (TGF)β-mediated suppression

While the effects of TCR affinity and TGFβ on CD8(+) T-cell function have been studied individually, the manner in which TCR affinity dictates susceptibility to TGFβ-mediated suppression remains unknown. To address this issue, we utilized OVA altered peptide ligands (APLs) of different affinities in...

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Bibliographic Details
Main Authors: O'Sullivan, Jeremy A., Zloza, Andrew, Kohlhapp, Frederick J., Moore, Tamson V., Lacek, Andrew T., Dulin, Nickolai O., Guevara-Patiño, José A.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3327162/
https://ncbi.nlm.nih.gov/pubmed/21681376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-011-1043-1
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