PTPN14 is required for the density-dependent control of YAP1

Through an shRNA-mediated loss-of-function screen, we identified PTPN14 as a potential tumor suppressor. PTPN14 interacts with yes-associated protein 1 (YAP1), a member of the hippo signaling pathway. We showed that PTPN14 promotes the nucleus-to-cytoplasm translocation of YAP1 during contact inhibi...

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Autori principali: Wang, Wenqi, Huang, Jun, Wang, Xin, Yuan, Jingsong, Li, Xu, Feng, Lin, Park, Jae-Il, Chen, Junjie
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2012
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435498/
https://ncbi.nlm.nih.gov/pubmed/22948661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.192955.112
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