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Oligomycin frames a common drug-binding site in the ATP synthase
We report the high-resolution (1.9 Å) crystal structure of oligomycin bound to the subunit c(10) ring of the yeast mitochondrial ATP synthase. Oligomycin binds to the surface of the c(10) ring making contact with two neighboring molecules at a position that explains the inhibitory effect on ATP synt...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3435195/ https://ncbi.nlm.nih.gov/pubmed/22869738 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207912109 |
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