Bedaquiline inhibits the yeast and human mitochondrial ATP synthases

Bedaquiline (BDQ, Sirturo) has been approved to treat multidrug resistant forms of Mycobacterium tuberculosis. Prior studies suggested that BDQ was a selective inhibitor of the ATP synthase from M. tuberculosis. However, Sirturo treatment leads to an increased risk of cardiac arrhythmias and death,...

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Pubblicato in:Commun Biol
Autori principali: Luo, Min, Zhou, Wenchang, Patel, Hiral, Srivastava, Anurag P., Symersky, Jindrich, Bonar, Michał M., Faraldo-Gómez, José D., Liao, Maofu, Mueller, David M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7438494/
https://ncbi.nlm.nih.gov/pubmed/32814813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01173-z
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