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Bedaquiline inhibits the yeast and human mitochondrial ATP synthases
Bedaquiline (BDQ, Sirturo) has been approved to treat multidrug resistant forms of Mycobacterium tuberculosis. Prior studies suggested that BDQ was a selective inhibitor of the ATP synthase from M. tuberculosis. However, Sirturo treatment leads to an increased risk of cardiac arrhythmias and death,...
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| 出版年: | Commun Biol |
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| 主要な著者: | , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7438494/ https://ncbi.nlm.nih.gov/pubmed/32814813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-020-01173-z |
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