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Oligomycin frames a common drug-binding site in the ATP synthase

We report the high-resolution (1.9 Å) crystal structure of oligomycin bound to the subunit c(10) ring of the yeast mitochondrial ATP synthase. Oligomycin binds to the surface of the c(10) ring making contact with two neighboring molecules at a position that explains the inhibitory effect on ATP synt...

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Bibliografiske detaljer
Main Authors: Symersky, Jindrich, Osowski, Daniel, Walters, D. Eric, Mueller, David M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3435195/
https://ncbi.nlm.nih.gov/pubmed/22869738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1207912109
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