Use of Kinase Inhibitors to Correct ΔF508-CFTR Function

The most common mutation in cystic fibrosis (CF) is a deletion of Phe at position 508 (ΔF508-CFTR). ΔF508-CFTR is a trafficking mutant that is retained in the ER, unable to reach the plasma membrane. To identify compounds and drugs that rescue this trafficking defect, we screened a kinase inhibitor...

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Bibliographic Details
Main Authors: Trzcińska-Daneluti, Agata M., Nguyen, Leo, Jiang, Chong, Fladd, Christopher, Uehling, David, Prakesch, Michael, Al-awar, Rima, Rotin, Daniela
Format: Artigo
Language:Inglês
Published: The American Society for Biochemistry and Molecular Biology 2012
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434788/
https://ncbi.nlm.nih.gov/pubmed/22700489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M111.016626
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