High-content Functional Screen to Identify Proteins that Correct F508del-CFTR Function

Cystic Fibrosis is caused by mutations in CFTR, with a deletion of a phenylalanine at position 508 (F508del-CFTR) representing the most common mutation. The F508del-CFTR protein exhibits a trafficking defect and is retained in the endoplasmic reticulum. Here we describe the development of a high-con...

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Bibliografiske detaljer
Main Authors: Trzcińska-Daneluti, Agata M., Ly, Diane, Huynh, Lise, Jiang, Chong, Fladd, Christopher, Rotin, Daniela
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2667356/
https://ncbi.nlm.nih.gov/pubmed/19088066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M800268-MCP200
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