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Uncoupling of eNOS causes superoxide anion production and impairs NO signaling in the cerebral microvessels of hph-1 mice

In the present study, we used the GTP cyclohydrolase I-deficient mice, ie., hph-1 mice, to test the hypothesis that the loss of tetrahydrobiopterin (BH(4)) in cerebral microvessels causes endothelial nitric oxide synthase (eNOS) uncoupling resulting in increased superoxide anion production and inhib...

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Autors principals: Santhanam, Anantha Vijay R, d'Uscio, Livius V., Smith, Leslie A, Katusic, Zvonimir S
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3433644/
https://ncbi.nlm.nih.gov/pubmed/22784235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2012.07872.x
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