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An Efficient Synthesis of Exo-N-carbamoyl Nucleosides: Application to the Synthesis of Phosphoramidate Prodrugs
[Image: see text] An efficient protection protocol for the 6-exo-amino group of purine nucleosides with various chloroformates was developed utilizing N-methyl imidazole (NMI). The reaction of an exo-N(6)-group of adenosine analog 1 with alkyl/ and aryl chloroformates under optimized conditions prov...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3432299/ https://ncbi.nlm.nih.gov/pubmed/22554490 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol300777p |
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